Inflammation at the cellular level is a common link among chronic illnesses.
I just learned about what appears to be a fantastic (and promising!) protocol created by Dr Dmitry Kats, PhD called The Niatonin Protocol that aims to help those who are suffering from Covid, Long-Haul Covid and Vaccine Injury to reduce inflammation and heal.
In the podcast and video above, Dr Kats explains how niacin and melatonin are integral to metabolic health and work together to push inflammation out of cells. Niacin reduces inflammation at the cellular level. Melatonin allows niacin to enter the cells.
Dr Kats explains the amazing chemical reactions that take place in the body. I had to watch this video several times to understand how the many interactions work. The body’s intelligence is fascinating!
Watch the masterclass at Paine.tv to learn from Dr Kats how energy is produced in the body and how niacin and melatonin work together to reduce inflammation.
In order for this protocol to work best, Dr Kats emphasizes you need to find your personal “sweet spot” dosage of melatonin and niacin – the dosage that allows the niacin to get into the cells without experiencing an uncomfortable “niacin flush” tingling, burning sensation. If you experience any tingling or discomfort, it’s a sign that your melatonin is depleted and you need to increase the melatonin dosage.
According to Dr Kats, you’ll know you’ve found your sweet spot dosage when you do not experience any flush, when there is no tingling whatsoever. If you have a lot of inflammation in your body, Dr Kats says you’ll need a lot more melatonin than someone who has little inflammation. Also, you’ll likely need to experiment on yourself to figure out your “sweet spot”.
One of the best things about the niatonin protocol is that it appears to be a much safer treatment option in the long-term, unlike pharmaceutical-based therapies. Ivermectin, for example, is reported to have harmful long-term neurological side effects.
That said, Dr Mercola did mention to “be careful, though, as using high-dose melatonin long term (doses of over 5 to 10 mg) are likely to draw out heavy metals like mercury and unless you are on a good detoxification program and using sauna regularly these heavy metals could cause biological damage.”
The niatonin protocol may also be beneficial to people with other chronic conditions that are rooted in inflammation. Read the stories shared by people on Telegram who are using this protocol to heal arthritis and other conditions.
I’m encouraged that The Niatonin Protocol may actually offer treatment to help people to heal – especially since doctors in general are not offering much support or guidance to people who are now experiencing vaccine injury or suffering from Covid and Long-Haul Covid.
I also love the fact that this protocol appears to be straightforward and simple, as well as, affordable. Dr Kats provides directions for The Niatonin Protocol here. For support with this protocol, join the Niatonin channel on Telegram.
Thank you Dr Kats for sharing your knowledge, educating us on metabolic processes and dedicating your time to answer so many questions to support people’s healing journey.
Excerpts from Dr Kats’ Masterclass on The Niatonin Protocol (Niacin + Melatonin)
“Lack of nutrients, especially niacin and melatonin, that can’t counter with the progression of a whole life course of continuous non-ideal or bad health behaviors, new exposures of our civilization like electronics, geo-thermal shifts, stressful life, poor quality food these days. Our continued dynamic deficiency, especially niatonin, leads to further accumulation of more and more energy not expended out per in, and so there’s free radical electrons formation and persistent over-accumulation that continues of inflammation.“
“What this etiology of clinical conditions in disease and the aging process in humans — this SAR-COVID2 viral species and this COVID pathogenesis is, is like what I just introduced you to, except it’s like the life course doing it slower, the virus and COVID is hyper accelerated. These viruses or if you’d like to call it “gain of function research” whatever it is, doesn’t matter — they’ve evolved since SARS1 in 2000, and what they’re targeting now are these energy metabolism receptors, also known as ACE2. What they’re also known as are GVR109A, aka HCA2, which is niacin’s innate high affinity – that’s what it binds to to do its role. And what melatonin regulates – and in a sense, is directly responsible for how much that receptor is regulated.”
“If you have high ACE2, it’s signaling that it’s feasting grounds for the virus. These viruses are thermodynamically attracted to people who have more inflammation that they can use for their fitness to replicate to straight thermodynamic progeny.”
“High expressed ACE2, aka the niacin receptor, along with what’s known as SRB-1 where HDL is scooping cholesterol that’s leaks out of macrophages back into them to prevent atherosclerosis, also known as CE36 genetic expression co-receptor of ACE2 which is right next to it. So, this is where the viruses sneak in.”
“The SRB-1 is where HDL dumps off cholesterol from blood back into tissue to prevent atherosclerosis. This cholesterol was leaking out of tissue after you accumulate too much inflammation because if you don’t have enough nutrients, especially these two in our diet (niacin and melatonin).”
“If you have a high ACE2 or SRB-1 receptor, that’s like us getting a free steak dinner at Ruth Chris. We used to go out to the woods to hunt but now we go to the supermarket. These viruses used to try to look for food and it was a lot harder and now they’ve evolved to know this receptor being highly expressed, along with SRB-1 next to it, this is why you see low HDLs. It’s getting used up trying to scoop the cholesterol back into the macrophages.”
“What it’s screaming is, “Hey, this guy has a whole lot of steak dinners and inflammation that’s easy to get to, so we’re going to sneak into this HDL cholesterol”. And the ACE2 is screaming, “Give me niacin. I haven’t had niacin my whole life. I have so much inflammation.”
“So the virus gets in to the cells and this is what you see, low HDL predicting so many diseases. Once the virus gets in, it starts consuming your energy until it reaches a threshold of this energy doubled. It depletes melatonin and makes it easier if you already have deficient melatonin coming in which is people (who) have high ACE2 and a lot of inflammation, they have depleted melatonin. This is why you also see people with cardio-metabolic risk factors in older adults who don’t have enough melatonin and niacin – and low HDL and high try-glycerides – being most at risk.”
“95% of melatonin is biosynthesized from tryptophan from food and drinks. Many people think melatonin has some regulation of circadian rhythm. Every single cell’s mitochondria, the melatonin is biosynthesized from triptophan. The 5% of melatonin released at night is recouped from the pineal gland that gets into circulation and gets into the cells. This is mainly because we don’t eat and drink while we’re sleeping. We have photo receptors that account for how much we’ll need based on exposure in the daytime that was used in the daytime to form tryptophan in all the cells.”
“The bio-synthesis of melatonin is 95% of it is from tryptophan getting into cells and going down the pathway to serotonin and melatonin. Next to this pathway is oxidative phosphorylation into the citric acid cycle like cellular respiration in the mitochondria. So this is the first step in, after you put food or drink in you, through the liver and into circulation.”
“Pyruvate is the precursor of the Acetyl-CoA. There’s an enzyme called the PDC enzyme. We call it the gatekeeper. The whole purpose from pyruvate to Acetyl-Coate, through the citric acid cycle – and what’s made from the citric acid cycle is ADP – the sole purpose for making ADP is to express the niacin receptor according to how much ATP or inflammation there is. What our body was engineered to do – the ADP is supposed to be made according to the corresponding volume of ATP.”
“With this inflammation, we are deficient in niacin for diet. If you continue to not make enough ADP – and what regulates ADP production is … if inflammation gets to be too much, and stress gets to be too much, then that PDC receptor gets damaged, inflamed, its function is down regulated. So, Acetyl-CoA is stunted in its biosynthesis.”
“As it goes through the citric acid cycle, Acetly-CoA plays another role in regulating the AA-NAT receptor which allows serotonin to trickle down to make melatonin. So, inflammation, over the life course, because you didn’t have enough niacin to address it … you can see how the oxidative stress can cascade then, so it will inflame that PDC receptor and stunt Acetyl-CoA biosynthesis which stunts production of melatonin.”
“It’s linking melatonin directly to keeping the citric acid cycle going. That’s the definition of anti-oxidation. That’s melatonin’s intrinsic role — to keep that oxidative stress there, to keep the citric acid cycle going, to make the corresponding amount of ADP to how much inflammation or ATP needs to be addressed, and for the niacin GPR109A receptor to be expressed for niacin to always be available to hit it. So once niacin gets into cells, it’s this holy molecule that has this exclusive endothermic process that gets into the mitochondria because of that receptor.”
“Over the life course, we don’t have enough melatonin and other nutrients from our diets. If you look at chess where the queen has the power role and the king is chilling, niacin is like the queen and melatonin is like the king.”
“Other health behaviors are like bishops, pawns.”
“Even if you exercise it out, you’re never going to slow the aging process of momentum damaging you.”
“Melatonin is supposed to set niacin up to continue to make Acetyl-CoA going down the citric acid cycle for the sole purpose of making corresponding ADP to how much ATP there is, for that ADP to be used for the expression of GPR109-A and ACE2 receptor and also, and know that the butyrate is also part of the expression with ADP in colon and blood brain barrier.”
“There must always be niacin to hit the receptor. And then niacin has a unique, beautiful endothermic process to result in potential energy. A bigger NAD+ and a huge NAADP for endolysosome formation in T cells, antivirals.”
“When you’re going from small molecules to these big ones, with more intake as niacin gets into the cells, it’s practically like exercising in a pill. The energy is exactly the same. Kinetic heat, potential energy is stored in idleness and contained in the bonds. If you move them, you release that energy. So when you exercise, you release.”
“Free radicals and inflammation, they go from higher energy states to less energy. This is how inflammation manifests. Melatonin allows niacin to come in, letting it know how much inflammation it needs to address.”
“There’s a difference between those energies — work energy and potential energy — it’s just the direction of the force.”
“If you can’t keep the citric acid cycle going to make enough ATP and you don’t have enough niacin, the PDC receptor is going to get more inflamed with more oxidative cascades and burn that receptor out. That will slow melatonin production. The pyruvate moves away from cellular metabolism from the mitochondria because the receptor is damaged. It leaves the mitochondria and does aerobic glycolysis. The inflammation over accumulates.”
“The last step of niacin from NAD to NAD+, the receptor that connects that is NaDC-1 which is glutamine dependent. So how rapidly the niacin drops trips out the NaDC-1 receptor glutauime. So glutamine is getting really used up and depleted.”
“Glutamine is the most abundant amino acid.”
“When niacin depletes rapidly, it depletes the receptor … and that’s when the virus gets into the cell.”
“Once it gets into the cell, it starts thirsting up your inflammation, your ATP, until it reaches a threshold where it’s enough to double. As it’s doing this, it’s further inflaming that PDC receptor. All the pathways of pro-inflammation are activated.”
“Melatonin regulates all gut microbial, intestinal health, digestive function and leaky gut.”
“The virus ultimately wants to get into your CNS (Central Nervous System) – that’s the most bang for the buck in terms of energy for its success. So, the cytokine storm is a strategy where you can damage the blood brain barrier through the circulation and get into the CNS then.”
“Another route is through the colon. So, as they’re replicating in the colon, it’s depleting the melatonin which is already deficient. It makes the gut leaky and through the vagus nerve it can cross into the blood brain barrier and then into the CNS and feast more.”
“It drains melatonin everywhere but especially in the colon.”
“Until you replete the melatonin, that GPR109A, ACE@ and butyrate, so the ADP can be made to have it expressed. And then you hit it with niacin and that clears the inflammation.”
“Flush is happening because not enough melatonin is available, only a proportion of ADP was made and only a proportion of that GPR/ACE2 was made and expressed. The ones (people) that require the most melatonin because there’s more inflammation, they require the most niacin to get in and address it. And proportionally, the most niacin doesn’t get into those cells. Instead, the niacin bounces off and hits the inside lining of the capillaries and does side reactions as it clears through the kidneys.”
“We’ve been dosing too high with the niacin thinking to embrace the flush but even if you embrace the flush, you’re not going to reset yourself or get the inflammation out until you embrace the melatonin to allow the corresponding expression of niacin receptor for that much niacin to hit it.”
“Niacin itself will help a lot but we’ve been mis-using it this whole time simply by not understanding the integral role of melatonin and niacin and the regulation of this receptor to be able to push out gunk and keep you in equilibrium.”
“Without melatonin, niacin does not get in the cells.”
The Connection of Melatonin and Niacin
“What these spikes do — they are taking over the receptors that niacin and melatonin regulate to get your energy for their fitness. The jabs are trying to get the amino-tech to be embedded in these receptors. This is theoretical but it would make sense – to remote zap our energy for harvest. That is how high their technology is now.”
“What this virus and what this disease is is not being able to tally up how much energy is in excess intracellularly through your body. This virus, these spikes, hyper accelerate that very thing. Niacin and melatonin regulate how much energy is balanced and move you back to a bioenergetic balance.”
“Thank goodness melatonin gets into cells, into the mitochondria. It doesn’t just biosynthesize from tryptophan.”
“The pineal gland release that happens at night to recoup what our photo receptors indicated it might have lost and may be needed at night to recoup because we’re not eating at night, that release of melatonin gets released into circulation and gets redirected to a melatonin receptor that allows entry directly into the mitochondria.”
“Oral supplementation through the liver — and the liver will push it up all the way through circulation. Melatonin allows more ATP to be formed so the citric acid cycle continues. More ATP so the niacin receptor can be expressed more, according to that inflammation. Assume you needed 30 mg of melatonin to replete all the melatonin to get the sufficient niacin receptor expression. So you hit, say, 1 gram of niacin. What you want is *no* flush, not even a tingle. So all that melatonin, all that niacin is used up — and eventually, it pushes out gunk and that inflammation is expelled out of the body. This inflammation, whether from the covid pathology or the vaccine injury potentially, let’s say. Or the life course of clinical conditions, pretty much every one.”
“Until you get that melatonin repleted, you’re going to just be flushing, especially the more depleted you are of melatonin. So this viral disease is hyper accelerating the life force presentation coming in. So this really depletes melatonin and this ultimately typifies what the really long covid is.”
“So what this is, is really a chemical reaction. You’re replenishing the substrates that got depleted in order to push out that inflammation as you hit these sweet spots more and more, to restore this receptor.”
“Ultimately restore tryptophan from melatonin. And then you won’t have to do as much melatonin each time.”
Re: covid long haulers …
“For the dosing of the melatonin, some people will need over 200 mg. And then hit it with the niacin.”
“The flush may be getting less and less and less but this is how melatonin got depleted.”
“There are older adults in their 70s and 80s who are requiring this much melatonin. So this is the key to always optimize efficient therapy or protection to keep you in balance.”
“What you always want is *no* flush. This flush is because there wasn’t enough melatonin for the niacin to get into cells. Once the threshold of the melatonin is met, hit it with the niacin and all that niacin is used and you don’t have the flush. You don’t have the bouncing off or the down-regulated GPR109 receptor because there wasn’t enough melatonin. There’s enough melatonin to make it express corresponding to how much inflammation needs to be addressed.”
“All that niacin — unless you do over 3 grams — as long as you have enough melatonin, all that niacin is going to get used up. And that’s when you want no flush, not even the slightest tingle — especially here in your face and cheeks where there’s the most inflammation.”
“With Long Covid, what’s going on is, as the niacin depletes, and you get over covid but this inflammation lingers, your melatonin depletes more and more. So with the niacin depleting, and melatonin depleting, tryptophan is depleting and getting oxidized. So this is going through your brain and CNS and your whole body. The tryptophan depletion is because of a lack of niacin and melatonin.”
“So Fluvoxamine and SSRIs are a horrible treatment strategy because you’re inhibiting serotonin, so you’re further inhibiting melatonin. (So you need to get enough melatonin to allow niacin to get out all of the inflammation.)”
“Inflammation is not allowing tryptophan and niacin to turn into protons.”
“This applies to every condition. The key things are these sweet spots. Ideally you want just enough melatonin, whatever it is. They’ve demonstrated that covid is ravaging you melatonin supply. If you keep your melatonin up, you prevent the virus from taking you to a more disease symptomatology.”
“Melatonin slows down the progression of the viral replication.”
“As comfortably as possible, get to the sweet spot dose. The sweet spot dose is: you never want to flush, not even a tingle. No flush niacin. Let’s say you get groggy and flush, that’s not enough melatonin. Even if it’s 500mg, you have to throw that melatonin in about 10 minutes before the niacin.”
Niacin:Melatonin Starting Dosages
“Start at about 300 mg niacin. This is in a non-urgent situation. Start at 20-25 mg melatonin.”
“PureBulk.com is the best. These are the most stable compounds. You’re putting into your body what is synthesized from food. We are where we are because we didn’t have enough from food. Its depletion is why you are where you are now.”
“Ideally, you want an immediate release (niacin) dump in your liver. Ideally, it’s powder, no fillers. If you can’t get powder, look for veggie cap — NOW brand is okay. You can take it out and put it in water.
If you have acute, severe covid, what you want is no flush.
If it’s mild, start with 500mg niacin and 60 mg melatonin. If it’s an acute case, do 50-60mg to start and 1gram niacin.”
“If it’s acute, judge the degree of the flush. If you have no flush, go up to 750mg niacin to push it out. The key is to give the necessary amount of melatonin. Get up to 1gram dose of niacin. Find the sweet spot — there should be no tingling.”
“What you want to do is expedite the queen in this game of chess to let it do its power. That’s what niacin is. It gets all the pathogens out.”
“Straight L-Glutamine. When you’re immune-suppressed, the glutamine continues to say deficient. Start wit 7-10 grams of L-Glutamine as a preset. Eventually melatonin will restore glutamine. This is a good igniter.”
“Once you get the inflammation out, it keeps ACE2 stabilized. What you want to do is take advantage of the dose response.”
The Niatonin Protocol
Get a precision 0.000 g scale to weigh the doses.
Take melatonin first, then the niacin 10 minutes later.
- PureBulk Niacin B3 Immediate Release
https://purebulk.com?sca_ref=1004090.8JspdBHd04. Use DMITRYKATS for 10% OFF
- PureBulk Melatonin (Powder): https://purebulk.com/products/melatonin
- BulkSupplements (second best option if PureBulk is out of stock)
“You want flush-inducing niacin, but you want enough melatonin in each cell so you actually do NOT flush (i.e., you get ALL of the niacin into cells that way, which is contingent upon the amount of melatonin in the cells to allow the needed amount of niacin … corresponding to how much excess ATP (/inflammation/oxidative stress/pathogen(s)/toxins/foreign particles:free radical electrons) there is inside cells needing to be addressed.” – Dr Kats
“Make sure it’s enough melatonin (and note it will all be used up too at sweet spots, along with the niacin) so ALL of the niacin is used up. And enough niacin on top to drive the gunk ALL out to reset metabolic homeostasis on the cellular level through all of the cells, and thus comprehensive health and functioning. It’s better to start on the heavy side with melatonin to ensure that all of the niacin is used up (and if so you don’t flush/tingle but are groggy and have excess bit of melatonin, you can hit it with a bit excess niacin thereafter to clear it (and do a bit more therapy) and/or adjust next dose accordingly to achieve the sweet spot by lowering melatonin and/or upping niacin).” – Dr Kats
Some Recommended Supplements To Support The Niatonin Protocol:
Dr Kats recommends a number of additional supplements to support the niatonin protocol. Search for each of these in the Telegram group to learn more about who should use these and when to use them. Join the Telegram as well for the most updated informaton.
L-Glutamine: it’s a good booster the first few days. Dr Kats says, “5 g doses for those with severe, acute” condition.
Magnesium Glycinate: helps promote glutathione
Vitamin B1/Thiamine: helps restore extensively depleted mitochondrial melatonin.
Real Vitamin C: bioavailable C (not straight ascorbic acid but with fruit fillers)
B-Supreme: expedites the sole citric acid cycle
Grass-fed Beef Liver (Morley Robbins protocol)
Bee Pollen: not too much, just a little
Copper Bisglycinate (THORNE):
NAC (N Acetyl Cysteine): only add after sweet spots established; ” for brain (and lungs, liver and heart) protection”; promotes glutathione more efficiently than glutathione supplementation, helps niacin preserve mitochondrial health.
ALCAR (Acetyl L CARnitine): “for detoxing brain from Ivermectin neurotoxicity”
GABA, L-Theanine or Butyrate, Acetyl Carnitine, Taurine: also for Ivermectin detox
Dandelion Leaf & Root Tea (with lemon + its zest) is a good buffer.
Additional metal chelation, beyond what melatonin does:
Curcumin, Actoferrin, Copper Bisglycinate, Zeolite, Fulvic Acid, IP6 (inositol) – look these up in the Telegram group.
Infrared Sauna after Niatonin or exercise
Niacin and Melatonin: Metabolic Health and COVID-19: https://onedaymd.aestheticsadvisor.com/2021/09/niacin-and-melatonin-metabolic-health.html
Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis?: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5929173/
Chronic Diseases Caused by Chronic Inflammation Require Chronic Treatment:
Anti-inflammatory Role of Dietary Spices: https://www.longdom.org/open-access/chronic-diseases-caused-by-chronic-inflammation-require-chronic-treatment-2155-9899.1000238.pdf
Join the Telegram group for a wealth of information and support: https://t.me/vaccinereversal
See the people who have been successfully treated, fully recovered: https://t.me/vaccinetreatment
Book a personalized consultation with Dr Kats: https://niatonin.youcanbook.me
Visit Dr Kats’ website: niacincurescovid.com